AUTHOR=Fang Xue , Kang Le , Qiu Yi-Fan , Li Zhao-Shen , Bai Yu 

TITLE=Yersinia enterocolitica in Crohn’s disease

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2023.1129996

DOI=10.3389/fcimb.2023.1129996

ISSN=2235-2988

ABSTRACT=<p>Increasing attention is being paid to the unique roles gut microbes play in both physiological and pathological processes. Crohn’s disease (CD) is a chronic, relapsing, inflammatory disease of the gastrointestinal tract with unknown etiology. Currently, gastrointestinal infection has been proposed as one initiating factor of CD. <italic>Yersinia enterocolitica</italic>, a zoonotic pathogen that exists widely in nature, is one of the most common bacteria causing acute infectious gastroenteritis, which displays clinical manifestations similar to CD. However, the specific role of <italic>Y. enterocolitica</italic> in CD is controversial. In this Review, we discuss the current knowledge on how <italic>Y. enterocolitica</italic> and derived microbial compounds may link to the pathogenesis of CD. We highlight examples of <italic>Y. enterocolitica</italic>-targeted interventions in the diagnosis and treatment of CD, and provide perspectives for future basic and translational investigations on this topic.</p>