AUTHOR=Yu Dingle , Guo Danchun , Zheng Yuejie , Yang Yonghong 

TITLE=A review of penicillin binding protein and group A Streptococcus with reduced-β-lactam susceptibility

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2023.1117160

DOI=10.3389/fcimb.2023.1117160

ISSN=2235-2988

ABSTRACT=<p>With the widespread use of antibiotics, antimicrobial resistance (AMR) has become a global problem that endangers public health. Despite the global high prevalence of group A <italic>Streptococcus</italic> (GAS) infections and the global widespread use of β-lactams, β-lactams remain the first-line treatment option for GAS infection. β-hemolytic streptococci maintain a persistent susceptibility to β-lactams, which is an extremely special phenomenon in the genus <italic>Streptococci</italic>, while the exact current mechanism is not known. In recent years, several studies have found that the gene encoding penicillin binding protein 2X (<italic>pbp2x</italic>) is associated with GAS with reduced-β-lactam susceptibility. The purpose of this review is to summarize the current published data on GAS penicillin binding proteins and β-lactam susceptibility, to explore the relationship between them, and to be alert to the emergence of GAS with reduced susceptibility to β-lactams.</p>