AUTHOR=Vega-Benedetti Ana Florencia , Loi Eleonora , Zavattari Patrizia TITLE=DNA methylation alterations caused by Leishmania infection may generate a microenvironment prone to tumour development JOURNAL=Frontiers in Cellular and Infection Microbiology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.984134 DOI=10.3389/fcimb.2022.984134 ISSN=2235-2988 ABSTRACT=
DNA methylation is an epigenetic signature consisting of a methyl group at the 5’ cytosine of CpG dinucleotides. Modifications in DNA methylation pattern have been detected in cancer and infectious diseases and may be associated with gene expression changes. In cancer development DNA methylation aberrations are early events whereas in infectious diseases these epigenetic changes may be due to host/pathogen interaction. In particular, in leishmaniasis, a parasitic disease caused by the protozoan