AUTHOR=Song Xiaonan , Wei Wei , Cheng Weijia , Zhu Huiyin , Wang Wei , Dong Haifeng , Li Jian 

TITLE=Cerebral malaria induced by plasmodium falciparum: clinical features, pathogenesis, diagnosis, and treatment

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.939532

DOI=10.3389/fcimb.2022.939532

ISSN=2235-2988

ABSTRACT=<p>Cerebral malaria (CM) caused by <italic>Plasmodium falciparum</italic> is a fatal neurological complication of malaria, resulting in coma and death, and even survivors may suffer long-term neurological sequelae. In sub-Saharan Africa, CM occurs mainly in children under five years of age. Although intravenous artesunate is considered the preferred treatment for CM, the clinical efficacy is still far from satisfactory. The neurological damage induced by CM is irreversible and lethal, and it is therefore of great significance to unravel the exact etiology of CM, which may be beneficial for the effective management of this severe disease. Here, we review the clinical characteristics, pathogenesis, diagnosis, and clinical therapy of CM, with the aim of providing insights into the development of novel tools for improved CM treatments.</p>