AUTHOR=Christodoulides Myron 

TITLE=Update on the Neisseria Macrophage Infectivity Potentiator-Like PPIase Protein

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.861489

DOI=10.3389/fcimb.2022.861489

ISSN=2235-2988

ABSTRACT=<p><italic>Neisseria</italic> pathogens express a Macrophage Infectivity Potentiator Protein (MIP), which belongs to the FK506 binding protein (FKBP) family of proteins that exhibit peptidyl-prolyl cis/trans isomerase (PPIase) activity. <italic>Neisseria</italic> MIP proteins are potential candidates for inclusion into vaccines for gonorrhoea caused by <italic>N. gonorrhoeae</italic> infection, and meningitis/sepsis caused by <italic>M. meningitidis</italic> infection. <italic>Neisseria</italic> MIP proteins are also potential targets for directed drug treatments, although this remains relatively unexplored. In this mini-review, we provide an update into the vaccine potential of <italic>Neisseria</italic> MIP and the few published drug targeting studies, and explore further the diversity of this protein amongst both pathogenic and commensal <italic>Neisseria</italic> spp.</p>