AUTHOR=Feng Guanrong , Zhang Duo , Peng Chengcheng , Wu Mingjiang , Xiao Pengpeng , Li Nan 

TITLE=Study on the Anti-Adenovirus Mechanism of Sargassum fusiforme

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.860559

DOI=10.3389/fcimb.2022.860559

ISSN=2235-2988

ABSTRACT=<p>Human adenovirus (HAdV) has a worldwide distribution and remains a major pathogen that leads to infections of the respiratory tract. No specific treatments or vaccines are yet available for HAdV infection. <italic>Sargassum fusiforme</italic>, an edible seaweed, has attracted a lot of attention for its various bioactivities. <italic>S. fusiforme</italic> has been reported to exhibit antiviral activity. However, research studies about its anti-HAdV activity are few. In this research, we found that <italic>S. fusiforme</italic> had low cytotoxicity and possessed anti-human adenovirus type 7 (HAdV7) activity <italic>in vitro</italic>, and the most effective ingredient was alginate. The time of addition assay demonstrated inhibitory effects that were observed in all life stages of the virus. In addition, we observed that the antiviral activity of alginate against HAdV7 infection might be closely related to the endoplasmic reticulum stress (ERS) pathway. Taken together, these results suggest that <italic>S. fusiforme</italic> extracts have potential application in the prevention and treatment of HAdV infection.</p>