AUTHOR=Wang Liqian , Li Danyang , Chen Zixi , He Liuqing , Wang Xianjun , Tao Liang 

TITLE=An Atypical Case of Monomicrobial Clostridioides difficile Septicemia With No Gastrointestinal Manifestations

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.853252

DOI=10.3389/fcimb.2022.853252

ISSN=2235-2988

ABSTRACT=<p>An uncommon case of monomicrobial <italic>Clostridioides difficile</italic> septicemia in a 63-year-old man was reported in Zhejiang, China. Once diagnosed, vancomycin treatment cleared the infections. The patient had no remarkable medical history, and the inspection showed no overt gastrointestinal symptoms, though <italic>C. difficile</italic> was detected in his stool samples. However, we later defined that the <italic>C. difficile</italic> strain isolated from the blood sample was different from the one isolated from his stool using the whole genome sequencing analysis. By retrospective analysis of his medical record, we noticed that the man had a recent tooth extraction thus the bacterium may have invaded through the root canal. Therefore, we suggest that oral <italic>C. difficile</italic> colonization may be a potential risk factor for severe <italic>C. difficile</italic> septicemia, which could be clinically alarming.</p>