AUTHOR=Zhou Shuhui , Ji Yaoting , Yao Hantao , Guo Haiying , Zhang Zichen , Wang Zijun , Du Minquan 

TITLE=Application of Ginsenoside Rd in Periodontitis With Inhibitory Effects on Pathogenicity, Inflammation, and Bone Resorption

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.813953

DOI=10.3389/fcimb.2022.813953

ISSN=2235-2988

ABSTRACT=<p>Periodontitis is a worldwide oral disease induced by the interaction of subgingival bacteria and host response and is characterized by local inflammation, bone resorption, and tooth loss. Ginsenoside Rd (Rd) is a biologically active component derived from Panax ginseng and has been demonstrated to exert antibacterial and anti-inflammatory activities. This study aims to investigate the inhibitory efficiency of Rd towards <italic>Porphyromonas gingivalis</italic> (<italic>P. gingivalis</italic>), periodontal inflammatory response, and osteoclastogenesis <italic>in vitro</italic> and to further validate the results in a mouse periodontitis model, thus, evaluate the potential effects of Rd on the control and prevention of periodontitis. According to the results, Rd exerted excellent antibacterial activities against planktonic <italic>P. gingivalis</italic>, along with attenuating <italic>P. gingivalis</italic> virulence and inhibiting its biofilms. Meanwhile, the inflammatory cytokine production and osteoclastogenesis were remarkably inhibited by Rd both <italic>in vitro</italic> and <italic>in vivo</italic>. Furthermore, Rd efficiently ameliorated the subgingival <italic>P. gingivalis</italic> abundance and suppressed the alveolar bone resorption <italic>in vivo</italic> as well. In conclusion, Rd has the potential to be developed as a promising medication in the control and prevention of periodontitis.</p>