AUTHOR=Taleb Zainab , Carmona-Alcocer Vania , Stokes Kyle , Haireek Marta , Wang Huaqing , Collins Stephen M. , Khan Waliul I. , Karpowicz Phillip TITLE=BMAL1 Regulates the Daily Timing of Colitis JOURNAL=Frontiers in Cellular and Infection Microbiology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.773413 DOI=10.3389/fcimb.2022.773413 ISSN=2235-2988 ABSTRACT=
Many physiological functions exhibit circadian rhythms: oscillations in biological processes that occur in a 24-hour period. These daily rhythms are maintained through a highly conserved molecular pacemaker known as the circadian clock. Circadian disruption has been proposed to cause increased risk of Inflammatory Bowel Disease (IBD) but the underlying mechanisms remain unclear. Patients with IBD experience chronic inflammation and impaired regeneration of intestinal epithelial cells. Previous animal-based studies have revealed that colitis models of IBD are more severe in mice without a circadian clock but the timing of colitis, and whether its inflammatory and regenerative processes have daily rhythms, remains poorly characterized. We tested circadian disruption using