AUTHOR=Guo Yang , Cao Xue-Shan , Zhou Meng-Ge , Yu Bo 

TITLE=Gastric microbiota in gastric cancer: Different roles of Helicobacter pylori and other microbes

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=12

YEAR=2023

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.1105811

DOI=10.3389/fcimb.2022.1105811

ISSN=2235-2988

ABSTRACT=<p>Gastric cancer (GC) is one of the leading causes of cancer-related deaths worldwide. The gastric microbiota plays a critical role in the development of GC. First, <italic>Helicobacter pylori</italic> (<italic>H. pylori</italic>) infection is considered a major risk factor for GC. However, recent studies based on microbiota sequencing technology have found that non-<italic>H. pylori</italic> microbes also exert effects on gastric carcinogenesis. Following the infection of <italic>H. pylori</italic>, gastric microbiota dysbiosis could be observed; the stomach is dominated by <italic>H. pylori</italic> and the abundances of non-<italic>H. pylori</italic> microbes reduce substantially. Additionally, decreased microbial diversity, alterations in the microbial community structure, negative interactions between <italic>H. pylori</italic> and other microbes, etc. occur, as well. With the progression of gastric lesions, the number of <italic>H. pylori</italic> decreases and the number of non-<italic>H. pylori</italic> microbes increases correspondingly. Notably, <italic>H. pylori</italic> and non-<italic>H. pylori</italic> microbes show different roles in different stages of gastric carcinogenesis. In the present mini-review, we provide an overview of the recent findings regarding the role of the gastric microbiota, including the <italic>H. pylori</italic> and non-<italic>H. pylori</italic> microbes, in the development of GC.</p>