AUTHOR=Jouault Albane , Saliba Alessandra Mattos , Touqui Lhousseine 

TITLE=Modulation of the immune response by the Pseudomonas aeruginosa type-III secretion system

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.1064010

DOI=10.3389/fcimb.2022.1064010

ISSN=2235-2988

ABSTRACT=<p><italic>Pseudomonas aeruginosa</italic> is an opportunistic pathogen that can cause critical cellular damage and subvert the immune response to promote its survival. Among the numerous virulence factors of <italic>P. aeruginosa</italic>, the type III secretion system (T3SS) is involved in host cell pathogenicity. Using a needle-like structure, T3SS detects eukaryotic cells and injects toxins directly into their cytosol, thus highlighting its ability to interfere with the host immune response. In this mini-review, we discuss how the T3SS and bacterial effectors secreted by this pathway not only activate the immune response but can also manipulate it to promote the establishment of <italic>P. aeruginosa</italic> infections.</p>