AUTHOR=Conde Luciana , Maciel Gabriela , de Assis Gustavo Meira , Freire-de-Lima Leonardo , Nico Dirlei , Vale André , Freire-de-Lima Célio Geraldo , Morrot Alexandre 

TITLE=Humoral response in Leishmaniasis

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.1063291

DOI=10.3389/fcimb.2022.1063291

ISSN=2235-2988

ABSTRACT=<p>Leishmaniasis presents different types of clinical manifestations that can be divided into cutaneous leishmaniasis and visceral leishmaniasis. The host’s immune system, associated with genetic and nutritional factors, is strongly involved in the evolution of the disease or parasite escape. Humoral immunity is characterized by the production of antibodies capable of promoting neutralization, opsonization, and activation of the complement system. In this scenario, B lymphocytes produce antibodies that play an important role in Leishmania infection although neglected for a long time. Thus, relevant aspects in the establishment of Leishmania infection will be addressed, highlighting the importance of humoral immunity during the entire process of Leishmania infection.</p>