AUTHOR=Peng Fei , Yi Qiong , Zhang Quan , Deng Jiayi , Li Cheng , Xu Min , Wu Chenfang , Zhong Yanjun , Wu Shangjie 

TITLE=Performance of D-dimer to lymphocyte ratio in predicting the mortality of COVID-19 patients

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.1053039

DOI=10.3389/fcimb.2022.1053039

ISSN=2235-2988

ABSTRACT=<sec><title>Background</title><p>Nowadays, there is still no effective treatment developed for COVID-19, and early identification and supportive therapies are essential in reducing the morbidity and mortality of COVID-19. This is the first study to evaluate D-dimer to lymphocyte ratio (DLR) as a prognostic utility in patients with COVID-19.</p></sec><sec><title>Methods</title><p>We retrospectively analyzed 611 patients and separated them into groups of survivors and non-survivors. The area under the curve (AUC) of various predictors integrated into the prognosis of COVID-19 was compared using the receiver operating characteristic (ROC) curve. In order to ascertain the interaction between DLR and survival in COVID-19 patients, the Kaplan-Meier (KM) curve was chosen.</p></sec><sec><title>Results</title><p>Age (<italic>OR</italic> = 1.053; 95% <italic>CI</italic>, 1.022-1.086; <italic>P</italic> = 0.001), NLR (<italic>OR</italic> = 1.045; 95% <italic>CI</italic>, 1.001-1.091; <italic>P</italic> = 0.046), CRP (<italic>OR</italic> = 1.010; 95% <italic>CI</italic>, 1.005-1.016; <italic>P</italic> &lt; 0.001), PT (<italic>OR</italic> = 1.184; 95% <italic>CI</italic>, 1.018-1.377; <italic>P</italic> = 0.029), and DLR (<italic>OR</italic> = 1.048; 95% <italic>CI</italic>, 1.018-1.078; <italic>P</italic> = 0.001) were the independent risk factors related with the mortality of COVID-19. DLR had the highest predictive value for COVID-19 mortality with the AUC of 0.924. Patients’ survival was lower when compared to those with lower DLR (Log Rank <italic>P &lt;</italic>0.001).</p></sec><sec><title>Conclusion</title><p>DLR might indicate a risk factor in the mortality of patients with COVID-19.</p></sec>