AUTHOR=Wu Di , Jia Yan , Cai Wenhao , Huang Yilin , Kattakayam Arjun , Latawiec Diane , Sutton Robert , Peng Jie 

TITLE=Impact of multiple drug-resistant Gram-negative bacterial bacteraemia on infected pancreatic necrosis patients

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.1044188

DOI=10.3389/fcimb.2022.1044188

ISSN=2235-2988

ABSTRACT=<sec><title>Introduction</title><p>Multiple drug-resistant Gram-negative bacterial (MDR-GNB) bacteraemia poses a serious threat to patients in hospital. Infected pancreatic necrosis (IPN) patients are a vulnerable population to infectious complications during hospitalization. This study aims to evaluate the impact of MDR Gram-negative bacteraemia on IPN patients.</p></sec><sec><title>Methods</title><p>A case–control study was performed with data collected from 1 January 2016 to 1 July 2022 in a Chinese tertiary teaching hospital. Clinical data of the IPN patients with MDR-GNB bacteraemia were analyzed and compared to those of a matched control group without MDR-GNB bacteraemia (case–control ratio of 1:2). Comparisons were performed between with/without MDR-GNB bacteraemia and different severities of acute pancreatitis (AP). Independent predictors of overall mortality were identified <italic>via</italic> univariate and multivariate binary logistic regression analyses.</p></sec><sec><title>Results</title><p>MDR-GNB bacteraemia was related to a higher mortality rate (62.5% vs. 8.3%, <italic>p</italic> &lt; 0.001). Severe AP combined with MDR-GNB bacteraemia further increased mortality up to 81.3% (<italic>p</italic> = 0.025). MDR-GNB bacteraemia (odds ratio (OR) = 8.976, 95% confidence interval (CI) = 1.805 –44.620, <italic>p</italic> = 0.007) and severe AP (OR = 9.414, 95% CI = 1.742 –50.873, <italic>p</italic> = 0.009) were independent predictors of overall mortality. MDR- <italic>Klebsiella pneumoniae</italic> was the most common causative pathogen.</p></sec><sec><title>Conclusion</title><p>A higher mortality rate in IPN patients was related to MDR-GNB bacteraemia and further increased in severe AP patients combined with MDR-GNB bacteraemia.</p></sec>