AUTHOR=Yang Chen , Huang Yemei , Zhou Yangyu , Zang Xuelei , Deng Hengyu , Liu Yitong , Shen Dingxia , Xue Xinying 

TITLE=Cryptococcus escapes host immunity: What do we know?

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.1041036

DOI=10.3389/fcimb.2022.1041036

ISSN=2235-2988

ABSTRACT=<p><italic>Cryptococcus</italic> is an invasive fungus that seriously endangers human life and health, with a complex and well-established immune-escaping mechanism that interferes with the function of the host immune system. <italic>Cryptococcus</italic> can attenuate the host’s correct recognition of the fungal antigen and escape the immune response mediated by host phagocytes, innate lymphoid cells, T lymphocytes, B lymphocytes with antibodies, and peripheral cytokines. In addition, the capsule, melanin, dormancy, Titan cells, biofilm, and other related structures of <italic>Cryptococcus</italic> are also involved in the process of escaping the host’s immunity, as well as enhancing the ability of <italic>Cryptococcus</italic> to infect the host.</p>