AUTHOR=Gil-Manso Sergio , Alonso Roberto , Catalán Pilar , Sánchez-Arcilla Ignacio , Marzola Marco , Correa-Rocha Rafael , Pion Marjorie , Muñoz Patricia , Gregorio Marañón Microbiology-ID COVID-19 Study Group , Alcalá Luis , Aldámiz Teresa , Alonso Roberto , Álvarez Beatriz , Álvarez-Uría Ana , Arias Alexi , Bermúdez Elena , Bouza Emilio , do-Serrano Sergio Buenesta , Burillo Almudena , Carrillo Raquel , Catalán Pilar , Cercenado Emilia , Cobos Alejandro , Díez Cristina , Escribano Pilar , Estévez Agustín , Fanciulli Chiara , Galar Alicia , García Mª Dolores , Viedma Darío García de , Gijón Paloma , González Adolfo , Guillén Helmuth , Herranz Jesús Guinea, Marta , Irigoyen Álvaro , Haces Laura Vanessa , Kestler Martha , López Juan Carlos , Losada Carmen Narcisa , Machado Marina , Marín Mercedes , Martín-Rabadán Pablo , Molero-Salinas Andrea , Muñoz Pedro Montilla, Patricia , Olmedo María , Padilla Belén , Palomino-Cabrera Rosalía , Palomo María , Pérez-Granda María Jesús , Peñas-Utrilla Daniel , Pérez-Lago Laura , Pérez Leire , Reigadas Elena , Rincón Cristina , Rodríguez Belén , Rodríguez Sara , Rodríguez-Grande Cristina , Rojas Adriana , Ruiz-Serrano María Jesús , Sánchez Carlos , Sánchez Mar , Sanz-Pérez Amadeo , Serrano Julia , Tejerina Francisco , Valerio Maricela , Veintimilla Mª Cristina , Vesperinas Lara , Vicente Teresa , Villa Sofíade la TITLE=IgG anti-RBD levels during 8-month follow-up post-vaccination with BNT162b2 and mRNA-1273 vaccines in healthcare workers: A one-center study JOURNAL=Frontiers in Cellular and Infection Microbiology VOLUME=12 YEAR=2022 URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.1035155 DOI=10.3389/fcimb.2022.1035155 ISSN=2235-2988 ABSTRACT=Introduction

Since the COVID-19 outbreak, specific mRNA-based anti-SARS-CoV-2 vaccines have been developed and distributed worldwide. Because this is the first time that mRNA vaccines have been used, there are several questions regarding their capacity to confer immunity and the durability of the specific anti-SARS-CoV-2 response. Therefore, the objective of this study was to recruit a large cohort of healthcare workers from the Gregorio Marañón Hospital vaccinated with the mRNA-1273 or BNT126b2 vaccines and to follow-up on IgG anti-RBD levels at 8 months post-vaccination.

Methods

We recruited 4,970 volunteers and measured IgG anti-RBD antibodies on days 30 and 240 post-vaccination.

Results

We observed that both vaccines induced high levels of antibodies on day 30, while a drastic wane was observed on day 240, where mRNA-1273 vaccinated induced higher levels than BNT162b2. Stratifying by vaccine type, age, gender, and comorbidities, we identified that older mRNA-1273-vaccinated volunteers had higher antibody levels than the younger volunteers, contrary to what was observed in the BNT162b2-vaccinated volunteers.

Discussion

In conclusion, we observed that mRNA-1273 has a higher capacity to induce a humoral response than BNT162b2 and that age is a factor in the specific response.