AUTHOR=Urrea-Quezada Alejandro , Balmaceda-Baca Ruben , Garibay Adriana , Hernández Jesús , Valenzuela Olivia 

TITLE=Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides From Cryptosporidium parvum

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=11

YEAR=2022

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2021.810887

DOI=10.3389/fcimb.2021.810887

ISSN=2235-2988

ABSTRACT=<p><italic>Cryptosporidium</italic> spp. are responsible for moderate to severe diarrhea, mainly in children and immunocompromised patients. Using ELISA, the recognition of synthetic peptides generated from the sequences of the <italic>Cryptosporidium parvum</italic> gp40 and gp15 proteins by serum IgM and IgG antibodies from patients infected (cases) with <italic>Cryptosporidium hominis</italic>, <italic>C. parvum</italic>, and <italic>Cryptosporidium canis</italic>, and uninfected individuals (controls) was evaluated. A statistically significant difference (p = 0.0025) was found in terms of the recognition of peptides A133 and A32 between cases and controls. Additional studies are necessary to understand the potential of these peptides as vaccine candidates.</p>