AUTHOR=Wang Mengyao , Fan Ziyao , Han Hongbing 

TITLE=Autophagy in Staphylococcus aureus Infection

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2021.750222

DOI=10.3389/fcimb.2021.750222

ISSN=2235-2988

ABSTRACT=<p><italic>Staphylococcus aureus</italic> is an invasive, facultative intracellular pathogen that can colonize niches in various host organisms, making it difficult for the host immune system to completely eliminate. Host autophagy is an intracellular clearance pathway involved in degrading <italic>S. aureus</italic>. Whereas the accessory gene regulatory system of <italic>S. aureus</italic> that controls virulence factors could resist the host immune defenses by evading and even utilizing autophagy. This article reviews the interaction between autophagy and <italic>S. aureus</italic>, providing insights on how to use these mechanisms to improve <italic>S. aureus</italic> infection control.</p>