AUTHOR=Sinclair Jane E. , Bloxham Conor J. , Chiu Han , Chew Keng Yih , Russell Jake , Yoshikawa Yusuke , Bielefeldt-Ohmann Helle , Steele Lauren E. , Hulme Katina D. , Verzele Nathalie AJ. , Noye Ellesandra C. , Wu Melanie , Reichelt Melissa E. , Thomas Walter G. , Gallo Linda A. , Redd Meredith A. , Short Kirsty R. 

TITLE=Type I Diabetes Mellitus Increases the Cardiovascular Complications of Influenza Virus Infection

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2021.714440

DOI=10.3389/fcimb.2021.714440

ISSN=2235-2988

ABSTRACT=<p>People with diabetes mellitus are susceptible to both cardiovascular disease and severe influenza A virus infection. We hypothesized that diabetes also increases risks of influenza-associated cardiac complications. A murine type 1 (streptozotocin-induced) diabetes model was employed to investigate influenza-induced cardiac distress. Lung histopathology and viral titres revealed no difference in respiratory severity between infected control and diabetic mice. However, compared with infected control mice, infected diabetic mice had increased serum cardiac troponin I and creatine-kinase MB, left ventricular structural changes and right ventricular functional alterations, providing the first experimental evidence of type I diabetes increasing risks of influenza-induced cardiovascular complications.</p>