AUTHOR=Liu Runqiu , Peng Cong , Jing Danrong , Xiao Yangjian , Zhu Wu , Zhao Shuang , Zhang Jianglin , Chen Xiang , Li Jie 

TITLE=Biomarkers of Gut Microbiota in Chronic Spontaneous Urticaria and Symptomatic Dermographism

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2021.703126

DOI=10.3389/fcimb.2021.703126

ISSN=2235-2988

ABSTRACT=<sec><title>Background</title><p>Chronic urticaria (CU) is a chronic inflammatory skin disease associated with Th2 immune response. The two most common subtypes of CU, i.e., chronic spontaneous urticaria and symptomatic dermographism (CSD), often coexist. However, the pathogenesis of CSD is still unclear. Gut microbiota plays an important role in immune-related inflammatory diseases. The purpose of this study was to explore the correlation between gut microbiota and CSD.</p></sec><sec><title>Methods</title><p>A case-control study was conducted on CSD patients as well as gender- and age-matched normal controls (NCs). The 16S ribosomal DNA sequencing of fecal samples was used to detect the gut microbiota of all subjects. QPCR was used to further verify the species with differences between the two groups.</p></sec><sec><title>Results</title><p>The alpha diversity of gut microbiota decreased in CSD patients, accompanied by significant changes of the structure of gut microbiota. <italic>Subdoligranulum</italic> and <italic>Ruminococcus bromii</italic> decreased significantly in CSD patients and had a potential diagnostic value for CSD according to receiver operating characteristic curve (ROC) analysis. <italic>Enterobacteriaceae</italic> and <italic>Klebsiella</italic> were found to be positively correlated with the duration of CSD, while <italic>Clostridium disporicum</italic> was positively correlated with the dermatology life quality index (DLQI).</p></sec><sec><title>Conclusions</title><p>The gut microbiota of CSD patients is imbalanced. <italic>Subdoligranulum</italic> and <italic>Ruminococcus bromii</italic> are the gut microbiota biomarkers in CSD.</p></sec>