AUTHOR=Moy Brian E. , Seshu J. 

TITLE=STAS Domain Only Proteins in Bacterial Gene Regulation

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2021.679982

DOI=10.3389/fcimb.2021.679982

ISSN=2235-2988

ABSTRACT=<p><underline>S</underline>ulfate <underline>T</underline>ransport <underline>A</underline>nti-<underline>S</underline>igma antagonist domains (Pfam01740) are found in all branches of life, from eubacteria to mammals, as a conserved fold encoded by highly divergent amino acid sequences. These domains are present as part of larger SLC26/SulP anion transporters, where the STAS domain is associated with transmembrane anchoring of the larger multidomain protein. Here, we focus on <underline>S</underline>TAS <underline>D</underline>omain <underline>o</underline>nly <underline>P</underline>roteins (SDoPs) in eubacteria, initially described as part of the <italic>Bacillus subtilis</italic><underline>R</underline>egulation of <underline>S</underline>igma <underline>B</underline> (RSB) regulatory system. Since their description in <italic>B. subtilis</italic>, SDoPs have been described to be involved in the regulation of sigma factors, through partner-switching mechanisms in various bacteria such as: <italic>Mycobacterium. tuberculosis, Listeria. monocytogenes, Vibrio. fischeri, Bordetella bronchiseptica</italic>, among others. In addition to playing a canonical role in partner-switching with an anti-sigma factor to affect the availability of a sigma factor, several eubacterial SDoPs show additional regulatory roles compared to the original RSB system of <italic>B. subtilis.</italic> This is of great interest as these proteins are highly conserved, and often involved in altering gene expression in response to changes in environmental conditions. For many of the bacteria we will examine in this review, the ability to sense environmental changes and alter gene expression accordingly is critical for survival and colonization of susceptible hosts.</p>