AUTHOR=Gu Mengmeng , Chen Nihong , Sun Huanhuan , Li Zhongyuan , Chen Xiangliang , Zhou Junshan , Zhang Yingdong TITLE=Roseburia Abundance Associates With Severity, Evolution and Outcome of Acute Ischemic Stroke JOURNAL=Frontiers in Cellular and Infection Microbiology VOLUME=11 YEAR=2021 URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2021.669322 DOI=10.3389/fcimb.2021.669322 ISSN=2235-2988 ABSTRACT=
Stroke induces disorder of gut microbiota, however, whether this disorder differs according to stroke severity and its role in the evolution and outcome of stroke is currently unknown. Here we explored the composition and structure of fecal microbiome based on 68 acute ischemic stroke patients presenting with minor symptoms (admission National Institute of Health Stroke Scale (NIHSS) ≤ 3) and 67 patients with non-minor stroke (admission NIHSS 4-34) using high-throughput Illumina sequencing of the 16S rRNA. There was no significant difference in α-diversity indices, but the principal coordinate analysis of the microbiota indicated clear separation of the two groups. The significantly enriched butyrate-producing genus