AUTHOR=König Constantin , Honecker Barbara , Wilson Ian W. , Weedall Gareth D. , Hall Neil , Roeder Thomas , Metwally Nahla Galal , Bruchhaus Iris 

TITLE=Taxon-Specific Proteins of the Pathogenic Entamoeba Species E. histolytica and E. nuttalli

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2021.641472

DOI=10.3389/fcimb.2021.641472

ISSN=2235-2988

ABSTRACT=<p>The human protozoan parasite <italic>Entamoeba histolytica</italic> can live in the human intestine for months or years without generating any symptoms in the host. For unknown reasons, amoebae can suddenly destroy the intestinal mucosa and become invasive. This can lead to amoebic colitis or extraintestinal amoebiasis whereby the amoebae spread to other organs <italic>via</italic> the blood vessels, most commonly the liver where abscesses develop. <italic>Entamoeba nuttalli</italic> is the closest genetic relative of <italic>E. histolytica</italic> and is found in wild macaques. Another close relative is <italic>E. dispar</italic>, which asyptomatically infects the human intestine. Although all three species are closely related, only <italic>E. histolytica</italic> and <italic>E. nuttalli</italic> are able to penetrate their host’s intestinal epithelium. Lineage-specific genes and gene families may hold the key to understanding differences in virulence among species. Here we discuss those genes found in <italic>E. histolytica</italic> that have relatives in only one or neither of its sister species, with particular focus on the peptidase, AIG, Ariel, and BspA families.</p>