AUTHOR=Elmi Abdi , Nasher Fauzy , Dorrell Nick , Wren Brendan , Gundogdu Ozan 

TITLE=Revisiting Campylobacter jejuni Virulence and Fitness Factors: Role in Sensing, Adapting, and Competing

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=10

YEAR=2021

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2020.607704

DOI=10.3389/fcimb.2020.607704

ISSN=2235-2988

ABSTRACT=<p><italic>Campylobacter jejuni</italic> is the leading cause of bacterial foodborne gastroenteritis world wide and represents a major public health concern. Over the past two decades, significant progress in functional genomics, proteomics, enzymatic-based virulence profiling (EBVP), and the cellular biology of <italic>C. jejuni</italic> have improved our basic understanding of this important pathogen. We review key advances in our understanding of the multitude of emerging virulence factors that influence the outcome of <italic>C. jejuni</italic>–mediated infections. We highlight, the spatial and temporal dynamics of factors that promote <italic>C. jejuni</italic> to sense, adapt and survive in multiple hosts. Finally, we propose cohesive research directions to obtain a comprehensive understanding of <italic>C. jejuni</italic> virulence mechanisms.</p>