AUTHOR=Kim Se-Hun , Chelliah Ramachandran , Ramakrishnan Sudha Rani , Perumal Ayyappasamy Sudalaiyadum , Bang Woo-Suk , Rubab Momna , Daliri Eric Banan-Mwine , Barathikannan Kaliyan , Elahi Fazle , Park Eunji , Jo Hyeon Yeong , Hwang Su-Bin , Oh Deog Hwan 

TITLE=Review on Stress Tolerance in Campylobacter jejuni

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=10

YEAR=2021

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2020.596570

DOI=10.3389/fcimb.2020.596570

ISSN=2235-2988

ABSTRACT=<p><italic>Campylobacter</italic> spp. are the leading global cause of bacterial colon infections in humans. Enteropathogens are subjected to several stress conditions in the host colon, food complexes, and the environment. Species of the genus <italic>Campylobacter</italic>, in collective interactions with certain enteropathogens, can manage and survive such stress conditions. The stress-adaptation mechanisms of <italic>Campylobacter</italic> spp. diverge from other enteropathogenic bacteria, such as <italic>Escherichia coli</italic>, <italic>Salmonella enterica</italic> serovar Typhi, <italic>S. enterica</italic> ser. Paratyphi, <italic>S. enterica</italic> ser. Typhimurium, and species of the genera <italic>Klebsiella</italic> and <italic>Shigella</italic>. This review summarizes the different mechanisms of various stress-adaptive factors on the basis of species diversity in <italic>Campylobacter</italic>, including their response to various stress conditions that enhance their ability to survive on different types of food and in adverse environmental conditions. Understanding how these stress adaptation mechanisms in <italic>Campylobacter</italic>, and other enteric bacteria, are used to overcome various challenging environments facilitates the fight against resistance mechanisms in <italic>Campylobacter</italic> spp., and aids the development of novel therapeutics to control <italic>Campylobacter</italic> in both veterinary and human populations.</p>