AUTHOR=Mukhopadhyay Debanjan , Arranz-Solís David , Saeij Jeroen P. J. 

TITLE=Influence of the Host and Parasite Strain on the Immune Response During Toxoplasma Infection

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2020.580425

DOI=10.3389/fcimb.2020.580425

ISSN=2235-2988

ABSTRACT=<p><italic>Toxoplasma gondii</italic> is an exceptionally successful parasite that infects a very broad host range, including humans, across the globe. The outcome of infection differs remarkably between hosts, ranging from acute death to sterile infection. These differential disease patterns are strongly influenced by both host- and parasite-specific genetic factors. In this review, we discuss how the clinical outcome of toxoplasmosis varies between hosts and the role of different immune genes and parasite virulence factors, with a special emphasis on <italic>Toxoplasma-</italic>induced ileitis and encephalitis.</p>