AUTHOR=Citro Simona , Bellini Alice , Medda Alessandro , Sabatini Maria Elisa , Tagliabue Marta , Chu Francesco , Chiocca Susanna 

TITLE=Human Papilloma Virus Increases ΔNp63α Expression in Head and Neck Squamous Cell Carcinoma

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2020.00143

DOI=10.3389/fcimb.2020.00143

ISSN=2235-2988

ABSTRACT=<p>P63, and in particular the most expressed ΔNp63α isoform, seems to have a critical role in the outcome of head and neck cancer. Many studies have been conducted to assess the possible use of p63 as a prognostic marker in squamous cell carcinoma cancers, but the results are still not well-defined. Moreover, a clear relationship between the expression of ΔNp63α and the presence of high-risk HPV E6 and E7 oncoproteins has been delineated. Here we describe how ΔNp63α is mostly expressed in HPV-positive compared to HPV-negative head and neck cancer cell lines, with a very good correlation between ΔNp63α mRNA and protein levels.</p>