AUTHOR=Kalejta Robert F. , Albright Emily R. 

TITLE=Expanding the Known Functional Repertoire of the Human Cytomegalovirus pp71 Protein

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2020.00095

DOI=10.3389/fcimb.2020.00095

ISSN=2235-2988

ABSTRACT=<p>The human cytomegalovirus pp71 protein is packaged within the tegument of infectious virions and performs multiple functions in host cells to prime them for productive, lytic replication. Here we review the known and hypothesized functions of pp71 in regulating proteolysis, infection outcome (lytic or latent), histone deposition, transcription, translation, immune evasion, cell cycle progression, and pathogenesis. We also highlight recent advances in CMV-based vaccine candidates informed by an improved understanding of pp71 function.</p>