AUTHOR=Doumatey Ayo P. , Adeyemo Adebowale , Zhou Jie , Lei Lin , Adebamowo Sally N. , Adebamowo Clement , Rotimi Charles N. TITLE=Gut Microbiome Profiles Are Associated With Type 2 Diabetes in Urban Africans JOURNAL=Frontiers in Cellular and Infection Microbiology VOLUME=10 YEAR=2020 URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2020.00063 DOI=10.3389/fcimb.2020.00063 ISSN=2235-2988 ABSTRACT=
Gut dysbiosis has been associated with several disease outcomes including diabetes in human populations. Currently, there are no studies of the gut microbiome composition in relation to type 2 diabetes (T2D) in Africans. Here, we describe the profile of the gut microbiome in non-diabetic adults (controls) and investigate the association between gut microbiota and T2D in urban West Africans. Gut microbiota composition was determined in 291 Nigerians (98 cases, 193 controls) using fecal 16S V4 rRNA gene sequencing done on the Illumina MiSeq platform. Data analysis of operational taxonomic units (OTU) was conducted to describe microbiome composition and identify differences between T2D and controls. The most abundant phyla were