AUTHOR=Li Zhendong , Quan Guomei , Jiang Xinyi , Yang Yang , Ding Xueyan , Zhang Dong , Wang Xiuqing , Hardwidge Philip R. , Ren Wenkai , Zhu Guoqiang TITLE=Effects of Metabolites Derived From Gut Microbiota and Hosts on Pathogens JOURNAL=Frontiers in Cellular and Infection Microbiology VOLUME=8 YEAR=2018 URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2018.00314 DOI=10.3389/fcimb.2018.00314 ISSN=2235-2988 ABSTRACT=

Intestinal metabolites participate in various physiological processes, including energy metabolism, cell-to-cell communication, and host immunity. These metabolites mainly originate from gut microbiota and hosts. Although many host metabolites are dominant in intestines, such as free fatty acids, amino acids and vitamins, the metabolites derived from gut microbiota are also essential for intestinal homeostasis. In addition, some metabolites are only generated and released by gut microbiota, such as bacteriocins, short-chain fatty acids, and quorum-sensing autoinducers. In this review, we summarize recent studies regarding the crosstalk between pathogens and metabolites from different sources, including the influence on bacterial development and the activation/inhibition of immune responses of hosts. All of these functions would affect the colonization of and infection by pathogens. This review provides clear ideas and directions for further exploring the regulatory mechanisms and effects of metabolites on pathogens.