AUTHOR=Yang Xiaobing , Pan Junfeng , Wang Yao , Shen Xihui 

TITLE=Type VI Secretion Systems Present New Insights on Pathogenic Yersinia

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=8

YEAR=2018

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2018.00260

DOI=10.3389/fcimb.2018.00260

ISSN=2235-2988

ABSTRACT=<p>The type VI secretion system (T6SS) is a versatile secretion system widely distributed in Gram-negative bacteria that delivers multiple effector proteins into either prokaryotic or eukaryotic cells, or into the extracellular milieu. T6SS participates in various physiological processes including bacterial competition, host infection, and stress response. Three pathogenic <italic>Yersinia</italic> species, namely <italic>Yersinia pestis, Yersinia pseudotuberculosis</italic>, and <italic>Yersinia enterocolitica</italic>, possess different copies of T6SSs with distinct biological functions. This review summarizes the pathogenic, antibacterial, and stress-resistant roles of T6SS in <italic>Yersinia</italic> and the ion-transporting ability in <italic>Y. pseudotuberculosis</italic>. In addition, the T6SS-related effectors and regulators identified in <italic>Yersinia</italic> are discussed.</p>