AUTHOR=Fan Xiude , Deng Huan , Sang Jiao , Li Na , Zhang Xiaoge , Han Qunying , Liu Zhengwen 

TITLE=High Serum Procalcitonin Concentrations in Patients With Hemorrhagic Fever With Renal Syndrome Caused by Hantaan Virus

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=8

YEAR=2018

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2018.00129

DOI=10.3389/fcimb.2018.00129

ISSN=2235-2988

ABSTRACT=<p><bold>Objective:</bold> This study analyzed the significance of procalcitonin (PCT) in patients with hemorrhagic fever with renal syndrome (HFRS) caused by Hantaan virus.</p><p><bold>Methods:</bold> The demographics and clinical and laboratory data including PCT at hospital admission in 146 adults with HFRS were retrospectively analyzed.</p><p><bold>Results:</bold> PCT level was significantly higher in severe patients (<italic>n</italic> = 72) than in mild patients (<italic>n</italic> = 74, <italic>p</italic> &lt; 0.001) and independently associated with disease severity (OR 2.544, 95% CI 1.330–4.868, <italic>p</italic> = 0.005). PCT had an area under the receiver operating characteristic curve (AUC) value of 0.738 (95% CI 0.657–0.820, <italic>p</italic> &lt; 0.001) for predicting severity. PCT level was significantly increased in patients with bacterial infection (<italic>n</italic> = 87) compared with those without (n = 59, <italic>p</italic> = 0.037) and associated with bacterial infection (OR 1.685, 95% CI 1.026–2.768, <italic>p</italic> = 0.039). The AUC value of PCT for predicting bacterial infection was 0.618 (95% CI 0.524–0.711, <italic>p</italic> = 0.016). PCT level was significantly elevated in non-survivors (<italic>n</italic> = 13) compared with survivors (<italic>n</italic> = 133, <italic>p</italic> &lt; 0.001) and independently associated with mortality (OR 1.075, 95% CI 1.003–1.152, <italic>p</italic> = 0.041). The AUC value of PCT for predicting mortality was 0.819 (95% CI 0.724–0.914, <italic>p</italic> &lt; 0.001).</p><p><bold>Conclusion:</bold> PCT concentrations at admission would be predictive of disease severity, secondary bacterial infection and mortality in patients with HFRS caused by Hantaan virus.</p>