AUTHOR=Prashar Akriti , Schnettger Laura , Bernard Elliott M. , Gutierrez Maximiliano G. 

TITLE=Rab GTPases in Immunity and Inflammation

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=7

YEAR=2017

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2017.00435

DOI=10.3389/fcimb.2017.00435

ISSN=2235-2988

ABSTRACT=<p>Strict spatiotemporal control of trafficking events between organelles is critical for maintaining homeostasis and directing cellular responses. This regulation is particularly important in immune cells for mounting specialized immune defenses. By controlling the formation, transport and fusion of intracellular organelles, Rab GTPases serve as master regulators of membrane trafficking. In this review, we discuss the cellular and molecular mechanisms by which Rab GTPases regulate immunity and inflammation.</p>