AUTHOR=Huang Ying , Wang Qi-long , Cheng Dan-dan , Xu Wen-ting , Lu Nong-hua 

TITLE=Adhesion and Invasion of Gastric Mucosa Epithelial Cells by Helicobacter pylori

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=6

YEAR=2016

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2016.00159

DOI=10.3389/fcimb.2016.00159

ISSN=2235-2988

ABSTRACT=<p><italic>Helicobacter pylori</italic> is the main pathogenic bacterium involved in chronic gastritis and peptic ulcer and a class 1 carcinogen in gastric cancer. Current research focuses on the pathogenicity of <italic>H. pylori</italic> and the mechanism by which it colonizes the gastric mucosa. An increasing number of <italic>in vivo</italic> and <italic>in vitro</italic> studies demonstrate that <italic>H. pylori</italic> can invade and proliferate in epithelial cells, suggesting that this process might play an important role in disease induction, immune escape and chronic infection. Therefore, to explore the process and mechanism of adhesion and invasion of gastric mucosa epithelial cells by <italic>H. pylori</italic> is particularly important. This review examines the relevant studies and describes evidence regarding the adhesion to and invasion of gastric mucosa epithelial cells by <italic>H. pylori</italic>.</p>