AUTHOR=Yen Hilo , Karino Masaki , Tobe Toru 

TITLE=Modulation of the Inflammasome Signaling Pathway by Enteropathogenic and Enterohemorrhagic Escherichia coli

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=6

YEAR=2016

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2016.00089

DOI=10.3389/fcimb.2016.00089

ISSN=2235-2988

ABSTRACT=<p>Innate immunity is an essential component in the protection of a host against pathogens. Enteropathogenic and enterohemorrhagic <italic>Escherichia coli</italic> (EPEC and EHEC, respectively) are known to modulate the innate immune responses of infected cells. The interference is dependent on their type III secretion system (T3SS) and T3SS-dependent effector proteins. Furthermore, these cytosolically injected effectors have been demonstrated to engage multiple immune signaling pathways, including the IFN/STAT, MAPK, NF-κB, and inflammasome pathways. In this review, recent work describing the interaction between EPEC/EHEC and the inflammasome pathway will be discussed.</p>