AUTHOR=Ost Michael , Singh Anurag , Peschel Andreas , Mehling Roman , Rieber Nikolaus , Hartl Dominik 

TITLE=Myeloid-Derived Suppressor Cells in Bacterial Infections

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=6

YEAR=2016

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2016.00037

DOI=10.3389/fcimb.2016.00037

ISSN=2235-2988

ABSTRACT=<p>Myeloid-derived suppressor cells (MDSCs) comprise monocytic and granulocytic innate immune cells with the capability of suppressing T- and NK-cell responses. While the role of MDSCs has been studied in depth in malignant diseases, the understanding of their regulation and function in infectious disease conditions has just begun to evolve. Here we summarize and discuss the current view how MDSCs participate in bacterial infections and how this knowledge could be exploited for potential future therapeutics.</p>