AUTHOR=Sharp Robert C. , Abdulrahim Muna , Naser Ebraheem S. , Naser Saleh A. TITLE=Genetic Variations of PTPN2 and PTPN22: Role in the Pathogenesis of Type 1 Diabetes and Crohn's Disease JOURNAL=Frontiers in Cellular and Infection Microbiology VOLUME=5 YEAR=2015 URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2015.00095 DOI=10.3389/fcimb.2015.00095 ISSN=2235-2988 ABSTRACT=
Genome wide association studies have identified several genes that might be associated with increase susceptibility to Type 1 Diabetes (T1D) and Crohn's disease. Both Crohn's disease and T1D have a profound impact on the lives of patients and it is pivotal to investigate the genetic role in patients acquiring these diseases. Understanding the effect of single nucleotide polymorphisms (SNP's) in key genes in patients suffering from T1D and Crohn's disease is crucial to finding an effective treatment and generating novel therapeutic drugs. This review article is focused on the impact of SNP's in