AUTHOR=Josse Jérôme , Velard Frédéric , Gangloff Sophie C. 

TITLE=Staphylococcus aureus vs. Osteoblast: Relationship and Consequences in Osteomyelitis

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=5

YEAR=2015

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2015.00085

DOI=10.3389/fcimb.2015.00085

ISSN=2235-2988

ABSTRACT=<p>Bone cells, namely osteoblasts and osteoclasts work in concert and are responsible for bone extracellular matrix formation and resorption. This homeostasis is, in part, altered during infections by <italic>Staphylococcus aureus</italic> through the induction of various responses from the osteoblasts. This includes the over-production of chemokines, cytokines and growth factors, thus suggesting a role for these cells in both innate and adaptive immunity. <italic>S. aureus</italic> decreases the activity and viability of osteoblasts, by induction of apoptosis-dependent and independent mechanisms. The tight relationship between osteoclasts and osteoblasts is also modulated by <italic>S. aureus</italic> infection. The present review provides a survey of the relevant literature discussing the important aspects of <italic>S. aureus</italic> and osteoblast interaction as well as the ability for antimicrobial peptides to kill intra-osteoblastic <italic>S. aureus</italic>, hence emphasizing the necessity for new anti-infectious therapeutics.</p>