AUTHOR=Shuang Li N., chuan Xie , hua Lu n.

TITLE=Transforming growth factor-β: an important mediator in Helicobacter pylori-associated pathogenesis

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=5

YEAR=2015

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2015.00077

DOI=10.3389/fcimb.2015.00077

ISSN=2235-2988

ABSTRACT=<p><italic>Helicobacter pylori (H.pylori)</italic> is a Gram-negative, microaerophilic, helical bacillus that specifically colonizes the gastric mucosa. The interaction of virulence factors, host genetic factors, and environmental factors contributes to the pathogenesis of <italic>H. pylori</italic>-associated conditions, such as atrophic gastritis and intestinal metaplasia. Infection with <italic>H. pylori</italic> has recently been recognized as the strongest risk factor for gastric cancer. As a pleiotropic cytokine, transforming growth factor (TGF)-β regulates various biological processes, including cell cycle, proliferation, apoptosis, and metastasis. Recent studies have shed new light on the involvement of TGF-β signaling in the pathogenesis of <italic>H. pylori</italic> infection. This review focuses on the potential etiological roles of TGF-β in <italic>H. pylori</italic>-mediated gastric pathogenesis.</p>