AUTHOR=Dandekar Thomas , Fieselmann Astrid , Fischer Eva , Popp Jasmin , Hensel Michael , Noster Janina 

TITLE=Salmonella—how a metabolic generalist adopts an intracellular lifestyle during infection

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=4

YEAR=2015

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2014.00191

DOI=10.3389/fcimb.2014.00191

ISSN=2235-2988

ABSTRACT=<p>The human-pathogenic bacterium <italic>Salmonella enterica</italic> adjusts and adapts to different environments while attempting colonization. In the course of infection nutrient availabilities change drastically. New techniques, “-omics” data and subsequent integration by systems biology improve our understanding of these changes. We review changes in metabolism focusing on amino acid and carbohydrate metabolism. Furthermore, the adaptation process is associated with the activation of genes of the <italic>Salmonella</italic> pathogenicity islands (SPIs). Anti-infective strategies have to take these insights into account and include metabolic and other strategies. <italic>Salmonella</italic> infections will remain a challenge for infection biology.</p>