AUTHOR=Cervantes Jorge L. , Hawley Kelly L. , Benjamin Sarah J. , Weinerman Bennett , Luu Stephanie M. , Salazar Juan C. 

TITLE=Phagosomal TLR signaling upon Borrelia burgdorferi infection

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=4

YEAR=2014

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2014.00055

DOI=10.3389/fcimb.2014.00055

ISSN=2235-2988

ABSTRACT=<p>Internalization and degradation of live Bb within phagosomal compartments of monocytes, macrophages and dendritic cells (DCs), allows for the release of lipoproteins, nucleic acids and other microbial products, triggering a broad and robust inflammatory response. Toll-like receptors (TLRs) are key players in the recognition of spirochetal ligands from whole viable organisms (i.e., vita-PAMPs). Herein we will review the role of endosomal TLRs in the response to the Lyme disease spirochete.</p>