AUTHOR=ROTUREAU Brice , VAN DEN ABBEELE Jan 

TITLE=Through the dark continent: African trypanosome development in the tsetse fly

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=3

YEAR=2013

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2013.00053

DOI=10.3389/fcimb.2013.00053

ISSN=2235-2988

ABSTRACT=<p>African trypanosomes are unicellular flagellated parasites causing trypanosomiases in Africa, a group of severe diseases also known as sleeping sickness in human and <italic>nagana</italic> in cattle. These parasites are almost exclusively transmitted by the bite of the tsetse fly. In this review, we describe and compare the three developmental programs of the main trypanosome species impacting human and animal health, with focus on the most recent observations. From here, some reflections are made on research issues concerning trypanosome developmental biology in the tsetse fly that are to be addressed in the future.</p>