AUTHOR=Semler Diana D., Lynch Karlene H., Dennis Jonathan J.

TITLE=The Promise of Bacteriophage Therapy for Burkholderia cepacia Complex Respiratory Infections

JOURNAL=Frontiers in Cellular and Infection Microbiology

VOLUME=1

YEAR=2012

URL=https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2011.00027

DOI=10.3389/fcimb.2011.00027

ISSN=2235-2988

ABSTRACT=<p>In recent times, increased attention has been given to evaluating the efficacy of phage therapy, especially in scenarios where the bacterial infectious agent of interest is highly antibiotic resistant. In this regard, phage therapy is especially applicable to infections caused by the <italic>Burkholderia cepacia</italic> complex (BCC) since members of the BCC are antibiotic pan-resistant. Current studies in BCC phage therapy are unique from many other avenues of phage therapy research in that the investigation is not only comprised of phage isolation, <italic>in vitro</italic> phage characterization and assessment of <italic>in vivo</italic> infection model efficacy, but also adapting aerosol drug delivery techniques to aerosol phage formulation delivery and storage.</p>