AUTHOR=Green Douglas R. TITLE=Not dead yet: cell death and survival in cancer and normal physiology JOURNAL=Frontiers in Cell Death VOLUME=3 YEAR=2024 URL=https://www.frontiersin.org/journals/cell-death/articles/10.3389/fceld.2024.1477346 DOI=10.3389/fceld.2024.1477346 ISSN=2813-5563 ABSTRACT=

For decades, we have assumed that all regulated cell death pathways have a dedicated “point of no return” that precedes death but after which cells are committed to die. The realization that this is often not the case represents what can be considered a paradigm shift in the field. Here we consider how cells can survive despite engagement of a cell death pathway and the consequences of a “near death experience” in cancer cells and possibly other physiological conditions.