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PERSPECTIVE article

Front. Cell Death
Sec. Cellular Stress and Survival: Crosslinks, Intersections, and Pathways
Volume 3 - 2024 | doi: 10.3389/fceld.2024.1467272
This article is part of the Research Topic Women in Cellular Stress and Survival Research View all articles

Mitochondrial (dys)function: a double edge sword in cell stress response

Provisionally accepted
Nicoletta Guaragnella Nicoletta Guaragnella *Maria Di Noia Maria Di Noia Angela Primavera Angela Primavera
  • Department of Biosciences, Biotechnologies, and Environment, University of Bari Aldo Moro, Bari, Italy

The final, formatted version of the article will be published soon.

    Mitochondria are multifaceted organelles acting as energy, metabolic and signaling hubs in the cells. They play a central role in biological processes aimed at maintaining cell homeostasis and regulating cell fate upon changing environments. Alterations in mitochondrial functions can affect cell stress response through different mechanisms, leading to adaptation or death. In this perspective, we focus on mitochondrial communication and its relevance for cytoprotective strategies aimed at controlling synthesis, degradation and recycling processes. The advantage of using yeast as a model organism for improving our understanding of the molecular mechanisms behind cell stress responses to mitochondrial dysfunction is described. New challenges for studying the interplay between mitochondrial retrograde signaling and autophagy/mitophagy pathways are highlighted.

    Keywords: Mitochondria, Cell stress response, yeast, retrograde signalling pathway, Autophagy, mitophagy

    Received: 19 Jul 2024; Accepted: 04 Dec 2024.

    Copyright: © 2024 Guaragnella, Di Noia and Primavera. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Nicoletta Guaragnella, Department of Biosciences, Biotechnologies, and Environment, University of Bari Aldo Moro, Bari, Italy

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.