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REVIEW article

Front. Cell Death
Sec. Non-Apoptotic Regulated Cell Death
Volume 3 - 2024 | doi: 10.3389/fceld.2024.1423805
This article is part of the Research Topic Grand Challenges in Cell Death Research View all articles

Non-canonical functions of regulated cell death machinery regulate cellular growth, invasion and the interplay between cell death modalities

Provisionally accepted
Yingquan Shan Yingquan Shan Bertrand Mollereau Bertrand Mollereau *
  • École Normale Supérieure de Lyon, Université de Lyon, Lyon, France

The final, formatted version of the article will be published soon.

    The exploration of multiple regulated cell death (RCD) pathways and the recognition that several cell death-related proteins, including caspases, serve non-canonical roles have significantly expanded and diversified cell death research. Caspases not only cleave cellular substrates, triggering apoptosis, but also impact essential processes such as cellular differentiation, proliferation, growth, and migration. These novel caspase-dependent regulatory networks are extensively studied during development, with Drosophila providing a diverse range of developmental models for investigating these phenomena. Moreover, recent insights into the non-canonical functions of cell death proteins have highlighted their pivotal role in cancer aggressiveness. Ultimately, understanding these non-canonical functions sheds light on the intricate connections between RCD pathways and their significance in promoting antioncogenic responses.

    Keywords: Apoptosis, Necrosis, Cancer, Migration, Drosophila

    Received: 26 Apr 2024; Accepted: 12 Jun 2024.

    Copyright: © 2024 Shan and Mollereau. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Bertrand Mollereau, École Normale Supérieure de Lyon, Université de Lyon, Lyon, France

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.