AUTHOR=Schofield James H. , Schafer Zachary T. 

TITLE=Regulators mount up: the metabolic roles of apoptotic proteins

JOURNAL=Frontiers in Cell Death

VOLUME=2

YEAR=2023

URL=https://www.frontiersin.org/journals/cell-death/articles/10.3389/fceld.2023.1223926

DOI=10.3389/fceld.2023.1223926

ISSN=2813-5563

ABSTRACT=<p>The induction of apoptosis, a programmed cell death pathway governed by activation of caspases, can result in fundamental changes in metabolism that either facilitate or restrict the execution of cell death. In addition, metabolic adaptations can significantly impact whether cells in fact initiate the apoptotic cascade. In this mini-review, we will highlight and discuss the interconnectedness of apoptotic regulation and metabolic alterations, two biological outcomes whose regulators are intertwined.</p>