REVIEW article
Front. Cell Dev. Biol.
Sec. Molecular and Cellular Pathology
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1600149
This article is part of the Research TopicAdvances in Immunobiology of InflammationView all articles
Molecular Dynamics of Inflammation Resolution: Therapeutic Implications
Provisionally accepted
Amro M. Soliman1*
Mohamed Soliman2Syed Sajid Hussain Shah3Habeeb Ali Baig2Nawal Salama Gouda2Bandar Theyab Alenezi4Awwad Alenezy5Ahmed M S M S Hegazy6Muhammad Jan4Elhassan Hussein Eltom4- 1Department of Biological Sciences, Faculty of Science, Concordia University of Edmonton, Edmonton, Canada
- 2Department of Microbiology, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia
- 3Department of Pathology, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia
- 4Department of Pharmacology, Faculty of Medicine, Northern Border University, Arar, Northern Borders, Saudi Arabia
- 5Department of Family and Community Medicine, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia
- 6Department of Anatomy, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia
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Inflammation is a critical part of innate immune response that is essential for exclusion of harmful stimuli and restoration of tissue homeostasis. Nonetheless, failure to resolve inflammation results in chronic inflammatory conditions, including autoimmune diseases. Conventionally, resolution of inflammation was deemed a passive process; however, evidence indicates that it entails active, highly regulated molecular and cellular events involving efferocytosis-driven macrophage reprogramming, post-transcriptional regulatory mechanisms and the production of specialized pro-resolving mediators (SPMs). These processes collectively restore tissue homeostasis and prevent chronic inflammation. Emerging therapeutic approaches targeting these pathways demonstrate promising results in preclinical studies and clinical trials, enhancing resolution and improving overall disease outcome. This resulted in a paradigm shift from conventional anti-inflammatory strategies to resolutionfocused treatment. Yet, challenges remain due to the complexity of resolution mechanisms and tissue-specific differences. This review summarizes current advances in inflammation resolution, emphasizing emerging concepts of resolution pharmacology. By employing endogenous mechanisms facilitating resolution, novel therapeutic applications can effectively manage several chronic inflammatory disorders.
Keywords: acute inflammation, Resolution, specialized pro-resolving molecules, proinflammatory pathways, Resolution Pharmacology
Received: 25 Mar 2025; Accepted: 23 Apr 2025.
Copyright: © 2025 Soliman, Soliman, Shah, Baig, Gouda, Alenezi, Alenezy, Hegazy, Jan and Eltom. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Amro M. Soliman, Department of Biological Sciences, Faculty of Science, Concordia University of Edmonton, Edmonton, Canada
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