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REVIEW article
Front. Cell Dev. Biol.
Sec. Cancer Cell Biology
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1587548
This article is part of the Research Topic Microbiota Homeostasis and Metabolic Reprogramming in Cancer Development and Digestive Diseases View all articles
Effects of anesthetics on development of gynecological cancer
Provisionally accepted- 1 Zhenjiang Fourth People's Hospital, Jiangsu, China
- 2 Jiangsu University Affiliated People's Hospital, Zhenjiang, Jiangsu Province, China
Gynecological cancers remain a leading cause of cancer among female patients, and surgery continues to be the primary therapeutic approach. Anesthesia is an indispensable component of perioperative period. In recent years, the influence of anesthesia drugs on cancer has become one of the focuses of anesthesiologists. Anesthetic drugs may influence cancer metabolic reprogramming and modulate immune function through the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS). Emerging evidence suggests that the choice of anesthetic agents could affect the prognosis of gynecological cancers. This review explores the relationship between anesthetic drugs and gynecological cancers (cervical cancer, ovarian cancer, and endometrial cancer), elucidating their effects on cancer prognosis through cellular pathways, metabolic regulation, and immune mechanisms. The findings aim to guide clinical decision-making and evaluate optimal perioperative anesthetic management strategies for gynecological cancer patients.
Keywords: cervical cancer, ovarian cancer, endometrial cancer, intravenous anesthetics, volatile anesthetics, Local anesthetics, Opioids, Dexamethasone
Received: 04 Mar 2025; Accepted: 01 Apr 2025.
Copyright: © 2025 Cheng, Wu and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yingxiang Cheng, Zhenjiang Fourth People's Hospital, Jiangsu, China
Lingzhong Xu, Zhenjiang Fourth People's Hospital, Jiangsu, China
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