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REVIEW article
Front. Cell Dev. Biol.
Sec. Cell Death and Survival
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1577382
This article is part of the Research Topic Ferroptosis, Cuproptosis, and Triaptosis: Unveiling Pathways and Translational Prospects View all 7 articles
Ferroptosis in Neurodegenerative Diseases: Mechanisms and Therapeutic Potential of Stem Cell Derivatives
Provisionally accepted
Ting Zhang 1,2
Yusu Zhang 1,2 Jinpeng Xie 1,2 Dandan Lu 3 Lihong Wang 1,2 Shuaifei Zhao 1,2 Jing Zhou 3,4
Yang Cheng 1,2 Ting Kou 1,2 Jue Wang 3 Ying Chen 1,2 Lei Xu 1,2 Xiangyu Hu 3 Yuxiu Ying 1,2 Jun Wang 3 Xiaoshuang Xin 1,2 Xu Xu 3 Siyun Lei 2 Chenyu Qiu 2 Jinhua Wu 1,2
Qiqi Lyu 5*
Tong Cao 2,3*- 1 School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China
- 2 Oujiang Laboratory, Wenzhou, China
- 3 School and hospital of Stomatology, Wenzhou Medical University, Wenzhou, China
- 4 Department of Stomatology, the Second Affiliated Hospital of Xinjiang Medical University, Xinjiang, China
- 5 Department of Neuroradiology, Singapore General Hospital, Singapore, Singapore
Ferroptosis, a non-apoptotic, iron-dependent form of regulated cell death, is closely related to the pathogenesis of neurodegenerative diseases. Stem cells and their derivatives exhibit remarkable potential in modulating ferroptosis , offering promising therapeutic intervention for neurodegenerative diseases. In this review, we systematically explore neurological aging and its association with cognitive impairment and neurodegenerative diseases, with focus on the molecular mechanisms of ferroptosis in neurodegenerative diseases and the potential therapeutic strategies of stem cell derivatives for neurological diseases.
Keywords: ferroptosis, Neurodegenerative Diseases, Aging, Stem Cell Derivatives, Neuroprotection
Received: 15 Feb 2025; Accepted: 10 Mar 2025.
Copyright: © 2025 Zhang, Zhang, Xie, Lu, Wang, Zhao, Zhou, Cheng, Kou, Wang, Chen, Xu, Hu, Ying, Wang, Xin, Xu, Lei, Qiu, Wu, Lyu and Cao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qiqi Lyu, Department of Neuroradiology, Singapore General Hospital, Singapore, Singapore
Tong Cao, School and hospital of Stomatology, Wenzhou Medical University, Wenzhou, China
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